Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001750)
Formula
UGT
SVG example
Reactant Niraparib metabolite M1 Product Niraparib metabolite M10
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronyltransferase (UGT) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001194 Indinavir sulfate Indinavir sulfate metabolite M1 Conjugation - Glucuronidation Indinavir sulfate [1]
MR001751 Niraparib Niraparib metabolite M1 Hydrolysis - Amide Hydrolysis Niraparib [2], [3]
References
1 Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A. Biochem Pharmacol. 1997 Apr 25;53(8):1187-95.
2 Human mass balance study and metabolite profiling of (14)C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer Invest New Drugs. 2017 Dec;35(6):751-765. doi: 10.1007/s10637-017-0451-2.
3 Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:14-21. doi: 10.1016/j.jchromb.2016.11.020.

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