Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR001750)
Formula	UGT
	Reactant	Niraparib metabolite M1		Product	Niraparib metabolite M10
	Reactant	Reactant Info		Product	Product Info
Metabolic Enzyme	UDP-glucuronyltransferase (UGT)					DME Info

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001194	Indinavir sulfate	Indinavir sulfate metabolite M1	Conjugation - Glucuronidation	Indinavir sulfate	[1]
MR001751	Niraparib	Niraparib metabolite M1	Hydrolysis - Amide Hydrolysis	Niraparib	[2], [3]

References
1	Hepatic and intestinal metabolism of indinavir, an HIV protease inhibitor, in rat and human microsomes. Major role of CYP3A. Biochem Pharmacol. 1997 Apr 25;53(8):1187-95.
2	Human mass balance study and metabolite profiling of (14)C-niraparib, a novel poly(ADP-Ribose) polymerase (PARP)-1 and PARP-2 inhibitor, in patients with advanced cancer Invest New Drugs. 2017 Dec;35(6):751-765. doi: 10.1007/s10637-017-0451-2.
3	Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:14-21. doi: 10.1016/j.jchromb.2016.11.020.

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