Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001813)
Formula
SVG example
Hydroxylation
Reactant Olaparib Product Olaparib metabolite M2,M5,M6,M7
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001815 Olaparib Olaparib metabolite M1 Hydrolysis - Amide Hydrolysis Olaparib [1]
MR001814 Olaparib Olaparib metabolite M10 Oxidation - Hydroxylation Olaparib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001809 Olaparib metabolite M2,M5,M6,M7 Olaparib metabolite M11 Other reaction - Dehydration Olaparib [1]
MR001808 Olaparib metabolite M2,M5,M6,M7 Olaparib metabolite M3 Oxidation - Alcohol Oxidation Olaparib [1]
MR001807 Olaparib metabolite M2,M5,M6,M7 Olaparib metabolite M8 Oxidation - Hydroxylation Olaparib [1]
References
1 In vitro metabolism of olaparib in liver microsomes by liquid chromatography/electrospray ionization high-resolution mass spectrometry Rapid Commun Mass Spectrom. 2020 Feb 15;34(3):e8575. doi: 10.1002/rcm.8575.

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