Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001851)
Formula
CYP3A4 ...
SVG example
Reactant Osimertinib Product AZ5104
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001852 Osimertinib AZ7550 Unclear Osimertinib [1], [2], [3]
MR001848 Osimertinib Osimertinib metabolite M1 Unclear Osimertinib [1]
MR001850 Osimertinib Osimertinib metabolite M17 Unclear Osimertinib [1]
MR001849 Osimertinib Osimertinib metabolite M18 Unclear Osimertinib [1]
MR001853 Osimertinib Osimertinib metabolite M2 Unclear Osimertinib [1]
MR001854 Osimertinib Osimertinib metabolite M8 Unclear Osimertinib [1]
References
1 Metabolic Disposition of Osimertinib in Rats, Dogs, and Humans: Insights into a Drug Designed to Bind Covalently to a Cysteine Residue of Epidermal Growth Factor Receptor Drug Metab Dispos. 2016 Aug;44(8):1201-12. doi: 10.1124/dmd.115.069203.
2 Population Pharmacokinetics, Pharmacogenomics, and Adverse Events of Osimertinib and its Two Active Metabolites, AZ5104 and AZ7550, in Japanese Patients with Advanced Non-small Cell Lung Cancer: a Prospective Observational Study. Invest New Drugs. 2023 Feb;41(1):122-133. doi: 10.1007/s10637-023-01328-9.
3 Instability Mechanism of Osimertinib in Plasma and a Solving Strategy in the Pharmacokinetics Study. Front Pharmacol. 2022 Jul 22;13:928983. doi: 10.3389/fphar.2022.928983.

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