Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001911)
Formula
SVG example
Hydroxylation
Reactant Palbociclib Product Palbociclib metabolite M6
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001913 Palbociclib Palbociclib metabolite M1 Oxidation - Hydroxylation Palbociclib [1]
MR001921 Palbociclib Palbociclib metabolite M10 Oxidation - N-Dealkylation Palbociclib [1]
MR001916 Palbociclib Palbociclib metabolite M11 Oxidation - Hydroxylation Palbociclib [1]
MR001922 Palbociclib Palbociclib metabolite M12 Unclear Palbociclib [1]
MR001923 Palbociclib Palbociclib metabolite M13 Conjugation - Acetylation Palbociclib [1]
MR001918 Palbociclib Palbociclib metabolite M14 Oxidation - N-Dealkylation Palbociclib [1]
MR001914 Palbociclib Palbociclib metabolite M2 Oxidation - Hydroxylation Palbociclib [1]
MR001915 Palbociclib Palbociclib metabolite M3 Oxidation - Hydroxylation Palbociclib [1]
MR001917 Palbociclib Palbociclib metabolite M4 Oxidation - N-Dealkylation Palbociclib [1]
MR001910 Palbociclib Palbociclib metabolite M5 Oxidation - Oxidation Palbociclib [1]
MR001912 Palbociclib Palbociclib metabolite M7 Oxidation - N-Oxidation Palbociclib [1]
MR001919 Palbociclib Palbociclib metabolite M8 Conjugation - Sulfation Palbociclib [1]
MR001920 Palbociclib Palbociclib metabolite M9 Oxidation - N-Dealkylation Palbociclib [1]
References
1 In vitro and in vivo metabolic investigation of the Palbociclib by UHPLC-Q-TOF/MS/MS and in silico toxicity studies of its metabolites J Pharm Biomed Anal. 2018 Aug 5;157:59-74. doi: 10.1016/j.jpba.2018.05.008.

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