Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR001972)
Formula
CYP3A5 ...
SVG example
N-Hydroxylation
Reactant Pentamidine isethionate Product Pentamidine Amidoxime
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A5 (CYP3A5) DME Info
Lauric acid omega-hydroxylase (CYP4A11) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Cytochrome P450 1A1 (CYP1A1) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001973 Pentamidine isethionate Pentamidine isethionate Unclear Pentamidine isethionate [1], [2]
References
1 Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42.
2 Value of preemptive CYP2C19 genotyping in allogeneic stem cell transplant patients considered for pentamidine administration. Clin Transplant. 2011 May-Jun;25(3):E271-5.

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