Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002021)
Formula	Conjugation
	Reactant	4-hydroxyphenobarbital	Product	Phenobarbital N-glucuronide
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Conjugation - Conjugation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR001974	Pentobarbital	4-hydroxyphenobarbital	Oxidation - Hydroxylation	Pentobarbital	[1]
MR002023	Phenobarbital	4-hydroxyphenobarbital	Oxidation - 4-Hydroxylation	Phenobarbital	[2]

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002022	4-hydroxyphenobarbital	Phenobarbital O-sulfate	Conjugation - Conjugation	Phenobarbital	[3]

References
1	CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):821-5.
2	Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
3	DrugBank(Pharmacology-Metabolism)Phenobarbital

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