Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002023)
Formula
CYP2C19 ...
SVG example
4-Hydroxylation
Reactant Phenobarbital Product 4-hydroxyphenobarbital
Reactant Info Product Info
Metabolic Enzyme Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Metabolic Type Oxidation - 4-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002024 Phenobarbital Mephobarbital Conjugation - Methylation Phenobarbital [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001974 Pentobarbital 4-hydroxyphenobarbital Oxidation - Hydroxylation Pentobarbital [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002021 4-hydroxyphenobarbital Phenobarbital N-glucuronide Conjugation - Conjugation Phenobarbital [1]
MR002022 4-hydroxyphenobarbital Phenobarbital O-sulfate Conjugation - Conjugation Phenobarbital [1]
References
1 DrugBank(Pharmacology-Metabolism)Phenobarbital
2 CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):821-5.

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