Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002057)
Formula
SVG example
N-Dealkylation
Reactant Piperacillin Product Desethyl-piperacillin
Reactant Info Product Info
Metabolic Enzyme Beta-lactamase (blaB) DME Info
Metabolic Type Oxidation - N-Dealkylation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002056 Desethyl-piperacillin Desethyl-piperacillin glucuronide Unclear Piperacillin [1], [2], [3]
References
1 The formation of desethyl-piperacillin from piperacillin by human liver S9 in vitro Biopharm Drug Dispos. 1997 Apr;18(3):185-90. doi: 10.1002/(sici)1099-081x(199704)18:3<185::aid-bdd10>3.0.co;2-u.
2 Determination of the antibiotic resistance rates of Serratia marcescens isolates obtained from various clinical specimens. Niger J Clin Pract. 2019 Jan;22(1):125-130.
3 In vitro and in vivo determination of piperacillin metabolism in humans Drug Metab Dispos. 2007 Mar;35(3):345-9. doi: 10.1124/dmd.106.012278.

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