Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002060)
Formula Reactant 5'-hydroxypiroxicam Product 5'-hydroxypiroxicam glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002064 Piroxicam 5'-hydroxypiroxicam Oxidation - 5'-Hydroxylation Piroxicam [1], [2]
MR002061 Carboxybenzothiazine metabolite Benzothiazine metabolite Unclear Piroxicam [1], [2]
MR008910 Piroxicam 5'-Hydroxypiroxicam Unclear - Unclear Ampiroxicam [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002062 Benzothiazine metabolite N-Methylsaccharin Unclear Piroxicam [1], [2]
References
1 In vivo Piroxicam Metabolites: Possible Source for Synthesis of Central Nervous System (CNS) Acting Depressants Cent Nerv Syst Agents Med Chem. 2017;17(3):172-177. doi: 10.2174/1871524917666161111093759.
2 Metabolism of piroxicam by laboratory animals Drug Metab Dispos. 1981 Mar-Apr;9(2):114-8.
3 Pharmacokinetic drug interactions between ampiroxicam and sulfaphenazole in rats

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