Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002064)
Formula
SVG example
5'-Hydroxylation
Reactant Piroxicam Product 5'-hydroxypiroxicam
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - 5'-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002066 Piroxicam Carboxybenzothiazine metabolite Unclear Piroxicam [1], [2]
MR002065 Piroxicam Cyclodehydrated metabolite Unclear Piroxicam [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002061 Carboxybenzothiazine metabolite Benzothiazine metabolite Unclear Piroxicam [1], [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002060 5'-hydroxypiroxicam 5'-hydroxypiroxicam glucuronide Conjugation - Glucuronidation Piroxicam [1], [2]
MR002062 Benzothiazine metabolite N-Methylsaccharin Unclear Piroxicam [1], [2]
References
1 In vivo Piroxicam Metabolites: Possible Source for Synthesis of Central Nervous System (CNS) Acting Depressants Cent Nerv Syst Agents Med Chem. 2017;17(3):172-177. doi: 10.2174/1871524917666161111093759.
2 Metabolism of piroxicam by laboratory animals Drug Metab Dispos. 1981 Mar-Apr;9(2):114-8.

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