Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002069)
Formula
UGT1A1 ...
SVG example
Glucuronidation
Reactant Pitavastatin Product Pitavastatin glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008868 Pitavastatin Pitavastatin metabolite M-13 Oxidation - Oxidation Pitavastatin [1]
MR008867 Pitavastatin Pitavastatin metabolite M-14 Oxidation - Oxidation Pitavastatin [1]
MR008864 Pitavastatin Pitavastatin metabolite M-3 Oxidation - Oxidation Pitavastatin [1]
MR008860 Pitavastatin Pitavastatin metabolite M-4 Unclear - Unclear Pitavastatin [1]
MR008869 Pitavastatin Pitavastatin metabolite M-6 Unclear - Unclear Pitavastatin [1]
MR008870 Pitavastatin Pitavastatin metabolite M-8 Unclear - Unclear Pitavastatin [1]
MR008857 Pitavastatin Pitavastatin-ester-Glu Unclear - Unclear Pitavastatin [1]
MR002068 Pitavastatin M-13 Oxidation - Oxidation Pitavastatin calcium [2]
MR002067 Pitavastatin M-3 Oxidation - Hydroxylation Pitavastatin calcium [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002070 Pitavastatin glucuronide Pitavastatin lactone Unclear Pitavastatin calcium [2]
References
1 Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: similarities and difference in the metabolism of pitavastatin in monkeys and humans
2 Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003 Jan;33(1):27-41.

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