Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002067)
Formula
SVG example
Hydroxylation
Reactant Pitavastatin Product M-3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008868 Pitavastatin Pitavastatin metabolite M-13 Oxidation - Oxidation Pitavastatin [1]
MR008867 Pitavastatin Pitavastatin metabolite M-14 Oxidation - Oxidation Pitavastatin [1]
MR008864 Pitavastatin Pitavastatin metabolite M-3 Oxidation - Oxidation Pitavastatin [1]
MR008860 Pitavastatin Pitavastatin metabolite M-4 Unclear - Unclear Pitavastatin [1]
MR008869 Pitavastatin Pitavastatin metabolite M-6 Unclear - Unclear Pitavastatin [1]
MR008870 Pitavastatin Pitavastatin metabolite M-8 Unclear - Unclear Pitavastatin [1]
MR008857 Pitavastatin Pitavastatin-ester-Glu Unclear - Unclear Pitavastatin [1]
MR002068 Pitavastatin M-13 Oxidation - Oxidation Pitavastatin calcium [2]
MR002069 Pitavastatin Pitavastatin glucuronide Conjugation - Glucuronidation Pitavastatin calcium [2]
References
1 Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: similarities and difference in the metabolism of pitavastatin in monkeys and humans
2 Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003 Jan;33(1):27-41.

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