Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002131)
Formula
SVG example
Hydroxylation
Reactant Prednisone Product 6alpha-hydroxy-prednisone (M-XIII)
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002769 Prednisone 17alpha,21-dihydroxy-pregnan-1,4,6-trien-3,11,30-trione (M-XVII) Unclear Prednisone [1]
MR002773 Prednisone 20alpha-dihydro-prednisone (M-V) Unclear Prednisone [1]
MR002772 Prednisone 20beta-dihydro-prednisone (M-IV) Unclear Prednisone [1]
MR002770 Prednisone 6beta-hydroxy-prednisone (M-XII) Oxidation - Hydroxylation Prednisone [1], [2]
MR002774 Prednisone Prednisolone Unclear Prednisone [1]
MR002132 Prednisone 20beta-dihydro-prednisone (M-IV) Unclear Prednisolone [1]
MR002130 Prednisone 6beta-hydroxy-prednisone (M-XII) Oxidation - Hydroxylation Prednisolone [1]
References
1 Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS J Mass Spectrom. 2015 Mar;50(3):633-42. doi: 10.1002/jms.3571.
2 Pharmacokinetic and pharmacoimmunodynamic interactions between prednisolone and sirolimus in adrenalectomized rats. J Pharmacokinet Biopharm. 1999 Feb;27(1):1-21.

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