Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002774)
Formula
SVG example
Reactant Prednisone Product Prednisolone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002769 Prednisone 17alpha,21-dihydroxy-pregnan-1,4,6-trien-3,11,30-trione (M-XVII) Unclear Prednisone [1]
MR002773 Prednisone 20alpha-dihydro-prednisone (M-V) Unclear Prednisone [1]
MR002772 Prednisone 20beta-dihydro-prednisone (M-IV) Unclear Prednisone [1]
MR002771 Prednisone 6alpha-hydroxy-prednisone (M-XIII) Oxidation - Hydroxylation Prednisone [1]
MR002770 Prednisone 6beta-hydroxy-prednisone (M-XII) Oxidation - Hydroxylation Prednisone [1], [2]
MR002132 Prednisone 20beta-dihydro-prednisone (M-IV) Unclear Prednisolone [1]
MR002131 Prednisone 6alpha-hydroxy-prednisone (M-XIII) Oxidation - Hydroxylation Prednisolone [1]
MR002130 Prednisone 6beta-hydroxy-prednisone (M-XII) Oxidation - Hydroxylation Prednisolone [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002758 Prednisolone 21-ethylcarbonate Prednisolone Oxidation - Hydroxylation Prednicarbate [3]
References
1 Detection and characterization of prednisolone metabolites in human urine by LC-MS/MS J Mass Spectrom. 2015 Mar;50(3):633-42. doi: 10.1002/jms.3571.
2 Pharmacokinetic and pharmacoimmunodynamic interactions between prednisolone and sirolimus in adrenalectomized rats. J Pharmacokinet Biopharm. 1999 Feb;27(1):1-21.
3 Prednicarbate biotransformation in human foreskin keratinocytes and fibroblasts Pharm Res. 1997 Jun;14(6):793-7. doi: 10.1023/a:1012162708675.

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