Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002147)
Formula
SVG example
Reactant Primaquine Product CPQ
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002142 Primaquine 2OH-PQ Oxidation - Hydroxylation Primaquine [1], [2]
MR002143 Primaquine 3OH-PQ Oxidation - Hydroxylation Primaquine [1], [2]
MR002144 Primaquine 4OH-PQ Oxidation - Hydroxylation Primaquine [1], [2]
MR002146 Primaquine 5OH-PQ Oxidation - Hydroxylation Primaquine [2]
MR002141 Primaquine PQ-Alc Unclear Primaquine [1]
MR002145 Primaquine PQ-N-CG Conjugation - Glucuronidation Primaquine [1], [3]
MR002148 Primaquine PQQI Unclear Primaquine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002137 CPQ CPOQ Unclear Primaquine [1]
MR002138 CPQ CPQ-G Conjugation - Glucuronidation Primaquine [1]
MR002136 CPQ CPQ-lac Unclear Primaquine [1]
References
1 Quantitative analysis of primaquine and its metabolites in human urine using liquid chromatography coupled with tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Dec 15;1213:123517. doi: 10.1016/j.jchromb.2022.123517.
2 Enantioselective metabolism of primaquine by human CYP2D6 Malar J. 2014 Dec 17;13:507. doi: 10.1186/1475-2875-13-507.
3 Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers. Drug Metab Pharmacokinet. 2022 Aug;45:100463. doi: 10.1016/j.dmpk.2022.100463.

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