Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002144)
Formula
SVG example
Hydroxylation
Reactant Primaquine Product 4OH-PQ
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002142 Primaquine 2OH-PQ Oxidation - Hydroxylation Primaquine [1], [2]
MR002143 Primaquine 3OH-PQ Oxidation - Hydroxylation Primaquine [1], [2]
MR002146 Primaquine 5OH-PQ Oxidation - Hydroxylation Primaquine [2]
MR002147 Primaquine CPQ Unclear Primaquine [1], [3], [4], [5]
MR002141 Primaquine PQ-Alc Unclear Primaquine [1]
MR002145 Primaquine PQ-N-CG Conjugation - Glucuronidation Primaquine [1], [3]
MR002148 Primaquine PQQI Unclear Primaquine [1]
References
1 Quantitative analysis of primaquine and its metabolites in human urine using liquid chromatography coupled with tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Dec 15;1213:123517. doi: 10.1016/j.jchromb.2022.123517.
2 Enantioselective metabolism of primaquine by human CYP2D6 Malar J. 2014 Dec 17;13:507. doi: 10.1186/1475-2875-13-507.
3 Comparative single dose pharmacokinetics and metabolism of racemic primaquine and its enantiomers in human volunteers. Drug Metab Pharmacokinet. 2022 Aug;45:100463. doi: 10.1016/j.dmpk.2022.100463.
4 Synthesis, Biological Activity and In Silico Pharmacokinetic Prediction of a New 2-Thioxo-Imidazoldidin-4-One of Primaquine. Pharmaceuticals (Basel). 2021 Feb 27;14(3):196. doi: 10.3390/ph14030196.
5 Quantitative determination of primaquine-5,6-ortho-quinone and carboxyprimaquine-5,6-ortho-quinone in human erythrocytes by UHPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2021 Jan 15;1163:122510. doi: 10.1016/j.jchromb.2020.122510.

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