Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002149)
Formula
CYP2E1 ...
SVG example
Reactant Primidone Product Phenylethylmalonamide (PEMA)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002150 Primidone Phenobarbital Unclear Primidone [1], [2], [3], [4]
References
1 Physiologically based pharmacokinetics model of primidone and its metabolites phenobarbital and phenylethylmalonamide in humans, rats, and mice Drug Metab Dispos. 1998 Jun;26(6):585-94.
2 Blood and cerebrospinal fluid pharmacokinetics of primidone and its primary pharmacologically active metabolites, phenobarbital and phenylethylmalonamide in the rat Eur J Drug Metab Pharmacokinet. 1999 Jul-Sep;24(3):255-64. doi: 10.1007/BF03190029.
3 Managing the Drug-Drug Interaction With Apixaban and Primidone: A Case Report. Hosp Pharm. 2023 Aug;58(4):345-349. doi: 10.1177/00185787221150928.
4 Ticagrelor and primidone interaction masquerading as dual antiplatelet therapy noncompliance. Future Cardiol. 2023 Jun 14. doi: 10.2217/fca-2023-0011.

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