Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002271)
Formula
SVG example
Reactant Siponimod Product Siponimod metabolite M6
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002272 Siponimod Siponimod metabolite M1 Oxidation - Hydroxylation Siponimod [1]
MR002273 Siponimod Siponimod metabolite M17 Unclear Siponimod [1]
MR002274 Siponimod Siponimod metabolite M2 Unclear Siponimod [1]
MR002269 Siponimod Siponimod metabolite M5 Unclear Siponimod [1]
MR002270 Siponimod Siponimod metabolite M7 Unclear Siponimod [1]
MR002275 Siponimod Siponimod metabolite M8 Unclear Siponimod [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009616 BAF-312 Siponimod M6 Oxidation - Hydroxylation BAF-312 [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009617 Siponimod M6 Siponimod M4c Oxidation - Sulfonation BAF-312 [1]
MR002268 Siponimod metabolite M6 Siponimod metabolite M4C Unclear Siponimod [1]
References
1 Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013.

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