Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002269)
Formula
SVG example
Reactant Siponimod Product Siponimod metabolite M5
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002272 Siponimod Siponimod metabolite M1 Oxidation - Hydroxylation Siponimod [1]
MR002273 Siponimod Siponimod metabolite M17 Unclear Siponimod [1]
MR002274 Siponimod Siponimod metabolite M2 Unclear Siponimod [1]
MR002271 Siponimod Siponimod metabolite M6 Unclear Siponimod [1]
MR002270 Siponimod Siponimod metabolite M7 Unclear Siponimod [1]
MR002275 Siponimod Siponimod metabolite M8 Unclear Siponimod [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009618 BAF-312 Siponimod M5 Oxidation - Hydroxylation BAF-312 [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009620 Siponimod M5 Siponimod M3 Conjugation - Glucuronidation BAF-312 [1]
MR009619 Siponimod M5 Siponimod M4a Oxidation - Sulfonation BAF-312 [1]
MR002265 Siponimod metabolite M5 Siponimod metabolite M3 Unclear Siponimod [1]
MR002264 Siponimod metabolite M5 Siponimod metabolite M4a Unclear Siponimod [1]
References
1 Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013.

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