Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002276)
Formula Reactant Sulfamethoxazole N4-hydroxylamine Product Nitroso-sulfamethoxazole
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002280 Sulfamethoxazole Sulfamethoxazole N4-hydroxylamine Oxidation - N-Hydroxylation Sulfamethoxazole [1], [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002277 Nitroso-sulfamethoxazole Sulfamethoxazole GSH conjugate Unclear Sulfamethoxazole [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling. J Immunol. 2007 May 1;178(9):5533-42.
3 The effect of cimetidine on the formation of sulfamethoxazole hydroxylamine in patients with human immunodeficiency virus. J Clin Pharmacol. 1998 May;38(5):463-6.

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