Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002280)
Formula
CYP3A4 ...
SVG example
N-Hydroxylation
Reactant Sulfamethoxazole Product Sulfamethoxazole N4-hydroxylamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Myeloperoxidase (MPO) DME Info
Metabolic Type Oxidation - N-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002281 Sulfamethoxazole 5-hydroxysulfamethoxazole Oxidation - 5-Hydroxylation Sulfamethoxazole [1]
MR002282 Sulfamethoxazole N-acetylsulfamethoxazole Conjugation - Acetylation Sulfamethoxazole [1]
MR002283 Sulfamethoxazole Sulfamethoxazole N-glucuronide Conjugation - N-Glucuronidation Sulfamethoxazole [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002276 Sulfamethoxazole N4-hydroxylamine Nitroso-sulfamethoxazole Unclear Sulfamethoxazole [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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