Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002285)
Formula Reactant Sulfapyridine Product N-acetylsufapyridine
Reactant Info Product Info
Metabolic Enzyme N-acetyltransferase 2 (NAT2) DME Info
Metabolic Type Conjugation - Acetylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002286 Sulfapyridine OH-sulfapyridine Oxidation - Hydroxylation Sulfapyridine [1]
MR002287 Sulfapyridine Sulfapyridine glucuronide Conjugation - Glucuronidation Sulfapyridine [2]
MR002293 Sulfapyridine OH-sulfapyridine Oxidation - Hydroxylation Sulfasalazine [1]
MR002294 Sulfapyridine Sulfapyridine glucuronide Conjugation - Glucuronidation Sulfasalazine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002284 N-acetylsufapyridine Acetylated sulfapyridine glucuronide Conjugation - Glucuronidation Sulfapyridine [2]
MR002288 N-acetylsufapyridine Acetylated sulfapyridine glucuronide Conjugation - Glucuronidation Sulfasalazine [2]
References
1 Effects of NAT2 polymorphism on SASP pharmacokinetics in Chinese population. Clin Chim Acta. 2009 Sep;407(1-2):30-5.
2 Small bowel absorption of sulfasalazine and its hepatic metabolism in human beings, cats, and rats Gastroenterology. 1979 Aug;77(2):280-4.

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