Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002296)
Formula
SVG example
Oxidation
Reactant Sumatriptan succinate Product Indole acetic acid
Reactant Info Product Info
Metabolic Enzyme Monoamine oxidase type A (MAO-A) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002297 Sumatriptan succinate Indole ethyl alcohol derivative Unclear Sumatriptan succinate [1]
MR002298 Sumatriptan succinate Sumatriptan metabolite GR34633 Oxidation - N-Demethylation Sumatriptan succinate [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009181 Indoleacetaldehyde Indole acetic acid Unclear - Unclear TRYPTAMINE [3], [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002295 Indole acetic acid Indole-3-Acetic-Acid-O-glucuronide Conjugation - O-Glucuronidation Sumatriptan succinate [1]
References
1 American Society of Health System Pharmacists; AHFS Drug Information 2009. Bethesda, MD. (2009), p. 2666
2 Disposition of sumatriptan in laboratory animals and humans Drug Metab Dispos. 1993 Sep-Oct;21(5):761-9.
3 Distribution and metabolism of tryptamine in rat brain
4 Tryptamine: a metabolite of tryptophan implicated in various neuropsychiatric disorders

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