Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002310)
Formula Reactant Suvorexant metabolite M4 Product Suvorexant metabolite M18
Reactant Info Product Info
Metabolic Type Oxidation - Hydoxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002308 hydroxyl-suvorexant Suvorexant metabolite M4 Oxidation - Oxidation Suvorexant [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002309 Suvorexant metabolite M4 Suvorexant metabolite M4 glucuronide Conjugation - Glucuronidation Suvorexant [2]
References
1 CYP450-Mediated metabolism of suvorexant and investigation of metabolites in forensic case specimens Forensic Sci Int. 2020 Jul;312:110307. doi: 10.1016/j.forsciint.2020.110307.
2 In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans Xenobiotica. 2016 Oct;46(10):882-95. doi: 10.3109/00498254.2015.1129565.

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