Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002318)
Formula Reactant 13-demethyl tacrolimus Product 13,15-didemethyl tacrolimus
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Deamination
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002319 Tacrolimus 13-demethyl tacrolimus Oxidation - Deamination Tacrolimus [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002317 13-demethyl tacrolimus 13,31-didemethyl tacrolimus Oxidation - Deamination Tacrolimus [1]
References
1 Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics Drug Metab Pharmacokinet. 2007 Oct;22(5):328-35. doi: 10.2133/dmpk.22.328.

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