Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002327)
Formula Reactant Tadalafil catechol Product Methyl Tadalafil catechol
Reactant Info Product Info
Metabolic Type Conjugation - Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002329 Tadalafil Tadalafil catechol Oxidation - Oxidation Tadalafil [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002328 Methyl Tadalafil catechol Methyl Tadalafil catechol glucuronide Conjugation - Glucuronidation Tadalafil [1]
References
1 Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats Pharmaceutics. 2019 Jul 20;11(7):354. doi: 10.3390/pharmaceutics11070354.
2 Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65.

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