Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002329)
Formula Reactant Tadalafil Product Tadalafil catechol
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002327 Tadalafil catechol Methyl Tadalafil catechol Conjugation - Methylation Tadalafil [1]
References
1 Effect of Ticagrelor, a Cytochrome P450 3A4 Inhibitor, on the Pharmacokinetics of Tadalafil in Rats Pharmaceutics. 2019 Jul 20;11(7):354. doi: 10.3390/pharmaceutics11070354.

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