Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002359)
Formula Reactant Tegaserod Product Tegaserod metabolite M45.3
Reactant Info Product Info
Metabolic Type Conjugation - N-Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002361 Tegaserod . Hydrolysis - Hydrolysis Tegaserod [1]
MR002360 Tegaserod O-desmethyl tegaserod Unclear Tegaserod [2]
MR002357 Tegaserod Tegaserod metabolite M43.2 Conjugation - N-Glucuronidation Tegaserod [1]
MR002358 Tegaserod Tegaserod metabolite M43.8 Conjugation - N-Glucuronidation Tegaserod [1]
References
1 Clinical pharmacokinetics of tegaserod, a serotonin 5-HT(4) receptor partial agonist with promotile activity Clin Pharmacokinet. 2002;41(13):1021-42. doi: 10.2165/00003088-200241130-00002.
2 In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions. Drug Metab Dispos. 2001 Oct;29(10):1269-76.

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