Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002393)
Formula Reactant Teniposide Product Teniposide catechol derivative
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - O-Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002398 Teniposide . Unclear Teniposide [1]
MR002395 Teniposide Cis-isomer of teniposide Unclear Teniposide [2]
MR002396 Teniposide Glucuronide of the aglycone Unclear Teniposide [2]
MR002394 Teniposide Hydroxy acid Unclear Teniposide [2]
MR002397 Teniposide O-demethylated Teniposide Unclear Teniposide [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002392 Teniposide catechol derivative Teniposide o-quinone derivative Unclear Teniposide [4]
References
1 Drug Interactions Flockhart Table:Docetaxel
2 The clinical pharmacology of etoposide and teniposide Clin Pharmacokinet. 1987 Apr;12(4):223-52. doi: 10.2165/00003088-198712040-00001.
3 PubChem:Teniposide
4 DrugBank(Pharmacology-Metabolism)Teniposide

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