Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002462)
Formula
SVG example
Demethylation
Reactant Trimipramine Product Desmethyltrimipramine
Reactant Info Product Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002463 Trimipramine 2-hydroxytrimipramine Oxidation - Hydroxylation Trimipramine [1], [2], [3]
References
1 Metabolism of trimipramine in vitro by human CYP2D6 isozyme Res Commun Chem Pathol Pharmacol. 1993 Oct;82(1):111-20.
2 Simultaneous determination of trimipramine and its major metabolites by high-performance liquid chromatography J Chromatogr. 1991 May 3;566(1):228-33. doi: 10.1016/0378-4347(91)80128-y.
3 Determination of trimipramine and metabolites in plasma by liquid chromatography with electrochemical detection J Pharm Sci. 1984 Dec;73(12):1745-8. doi: 10.1002/jps.2600731221.

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