Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002487)
Formula
CYP2B6 ...
SVG example
5-Hydroxylation
Reactant 2-N-Propyl-4-oxopentanoic acid Product 2-Propylsuccinic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2A6 (CYP2A6) DME Info
Metabolic Type Oxidation - 5-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002486 4-hydroxyvalproic acid 2-N-Propyl-4-oxopentanoic acid Oxidation - Dehydrogenation Valproic acid [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 PharmGKB: the Pharmacogenomics Knowledge Base Methods Mol Biol. 2013;1015:311-20. doi: 10.1007/978-1-62703-435-7_20.

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