Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR002594)
Formula	Glucuronidation
	Reactant	2-hydroxydesipramine		Product	2-hydroxy-desipramine glucuronide
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Conjugation - Glucuronidation

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Produce The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR002595	Desipramine	2-hydroxydesipramine	Oxidation - 2-Hydroxylation	Desipramine	[1]
MR012987	Desipramine	2-hydroxydesipramine	Oxidation - Hydrolyzationn	Imipramine hydrochloride	[2]

References
1	Clinical pharmacokinetics of imipramine and desipramine
2	The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

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