General Information of This Metabolic Reaction (MR) (ID: MR002594)
Formula
SVG example
Glucuronidation
Reactant 2-hydroxydesipramine Product 2-hydroxy-desipramine glucuronide
Reactant Info Product Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002595 Desipramine 2-hydroxydesipramine Oxidation - 2-Hydroxylation Desipramine [1]
MR012987 Desipramine 2-hydroxydesipramine Oxidation - Hydrolyzationn Imipramine hydrochloride [2]
References
1 Clinical pharmacokinetics of imipramine and desipramine
2 The Use of In Vitro Data and Physiologically-Based Pharmacokinetic Modeling to Predict Drug Metabolite Exposure: Desipramine Exposure in Cytochrome P4502D6 Extensive and Poor Metabolizers Following Administration of Imipramine

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