Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002595)
Formula
SVG example
2-Hydroxylation
Reactant Desipramine Product 2-hydroxydesipramine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - 2-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004626 Desipramine 2-OH-desipramine Unclear Imipramine oxide [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002594 2-hydroxydesipramine 2-hydroxy-desipramine glucuronide Conjugation - Glucuronidation Desipramine [2]
MR012988 2-hydroxydesipramine 2-hydroxydesipramine glucuronide Conjugation - O-glucuronidation Imipramine hydrochloride [2]
References
1 Imipramine metabolites in blood of patients during therapy and after overdose
2 Clinical pharmacokinetics of imipramine and desipramine

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