Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002606)
Formula
SVG example
Hydroxylation
Reactant 5-hydroxy diclofenac Product 4',5-Dihydroxydiclofenac
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002614 Diclofenac sodium 5-hydroxy diclofenac Oxidation - 5-Hydroxylation Diclofenac sodium [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002607 5-hydroxy diclofenac 5,N-dihydroxy diclofenac Oxidation - N-Hydroxylation Diclofenac sodium [3]
MR002605 5-hydroxy diclofenac 5-hydroxy-4-glutathione conjugated diclofenac Conjugation - Glutathione Conjugation Diclofenac sodium [3]
MR002604 5-hydroxy diclofenac 5-hydroxy-6-glutathione conjugated diclofenac Conjugation - Glutathione Conjugation Diclofenac sodium [3]
References
1 Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis Eur J Clin Pharmacol. 1983;25(3):389-94. doi: 10.1007/BF01037953.
2 Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron-capture detection J Chromatogr. 1981 Nov 6;217:263-71. doi: 10.1016/s0021-9673(00)88081-4.
3 DrugBank(Pharmacology-Metabolism)Diclofenac sodium

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