Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002614)
Formula
CYP3A4 ...
SVG example
5-Hydroxylation
Reactant Diclofenac sodium Product 5-hydroxy diclofenac
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - 5-Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002612 Diclofenac sodium 3'-hydroxydiclofenac Oxidation - 3'-Hydroxylation Diclofenac sodium [1], [2]
MR002613 Diclofenac sodium 4'-hydroxydiclofenac Oxidation - 4'-Hydroxylation Diclofenac sodium [3], [1], [2]
MR002616 Diclofenac sodium Diclofenac 2',3'-oxide Unclear Diclofenac sodium [4]
MR002618 Diclofenac sodium Diclofenac acyl glucuronide Conjugation - Glucuronidation Diclofenac sodium [4]
MR002615 Diclofenac sodium Diclofenac o-imine methine Oxidation - Oxidative Decarboxylation Diclofenac sodium [4]
MR002617 Diclofenac sodium Diclofenac radical Oxidation - Oxidation Diclofenac sodium [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002606 5-hydroxy diclofenac 4',5-Dihydroxydiclofenac Oxidation - Hydroxylation Diclofenac sodium [1]
MR002607 5-hydroxy diclofenac 5,N-dihydroxy diclofenac Oxidation - N-Hydroxylation Diclofenac sodium [4]
MR002605 5-hydroxy diclofenac 5-hydroxy-4-glutathione conjugated diclofenac Conjugation - Glutathione Conjugation Diclofenac sodium [4]
MR002604 5-hydroxy diclofenac 5-hydroxy-6-glutathione conjugated diclofenac Conjugation - Glutathione Conjugation Diclofenac sodium [4]
References
1 Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis Eur J Clin Pharmacol. 1983;25(3):389-94. doi: 10.1007/BF01037953.
2 Simultaneous determination of diclofenac sodium and its hydroxy metabolites by capillary column gas chromatography with electron-capture detection J Chromatogr. 1981 Nov 6;217:263-71. doi: 10.1016/s0021-9673(00)88081-4.
3 Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls Clin Pharmacokinet. 1997 Sep;33(3):184-213. doi: 10.2165/00003088-199733030-00003.
4 DrugBank(Pharmacology-Metabolism)Diclofenac sodium

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