Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002695)
Formula
SVG example
Reactant 4-hydroxyestrone Product 4-methoxyestrone
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013315 E-3A 4-hydroxyestrone Oxidation - 4-hydroxylation E-3A [1]
MR002697 Estrone 4-hydroxyestrone Oxidation - 4-Hydroxylation Estrone [2]
MR002627 Estradiol 4-hydroxyestrone Oxidation - 4-Hydroxylation Estradiol acetate [3]
MR002650 Estradiol 4-hydroxyestrone Oxidation - 4-Hydroxylation Estradiol cypionate [3]
MR002673 Estradiol 4-hydroxyestrone Oxidation - 4-Hydroxylation Estradiol valerate [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013316 4-hydroxyestrone 4-Hydroxyestradiol Unclear E-3A [4]
MR002643 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol acetate [5]
MR002666 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol cypionate [5]
MR002689 4-hydroxyestrone 4-hydroxyestradiol Unclear Estradiol valerate [5]
References
1 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
2 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
3 The metabolism of estradiol; oral compared to intravenous administration J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8.
4 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
5 Cytochrome P450-mediated metabolism of estrogens and its regulation in human Cancer Lett. 2005 Sep 28;227(2):115-24. doi: 10.1016/j.canlet.2004.10.007.

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