Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002666)
Formula
SVG example
Reactant 4-hydroxyestrone Product 4-hydroxyestradiol
Reactant Info Product Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013315 E-3A 4-hydroxyestrone Oxidation - 4-hydroxylation E-3A [1]
MR002697 Estrone 4-hydroxyestrone Oxidation - 4-Hydroxylation Estrone [2]
MR002627 Estradiol 4-hydroxyestrone Oxidation - 4-Hydroxylation Estradiol acetate [3]
MR002650 Estradiol 4-hydroxyestrone Oxidation - 4-Hydroxylation Estradiol cypionate [3]
MR002673 Estradiol 4-hydroxyestrone Oxidation - 4-Hydroxylation Estradiol valerate [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002695 4-hydroxyestrone 4-methoxyestrone Unclear Estrone [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR004105 Conjugated estrogens 4-Hydroxyestradiol Oxidation - Hydrolyzationn Conjugated estrogens [5]
MR013318 E-3A 4-Hydroxyestradiol Unclear E-3A [1]
MR002626 Estradiol 4-hydroxyestradiol Unclear Estradiol acetate [6]
MR002649 Estradiol 4-hydroxyestradiol Oxidation - Hydroxylation Estradiol cypionate [6]
MR002672 Estradiol 4-hydroxyestradiol Oxidation - Hydroxylation Estradiol valerate [6]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013319 4-Hydroxyestradiol 4-methoxyestradiol Unclear E-3A [1]
MR002642 4-hydroxyestradiol 4-methoxyestradiol Unclear Estradiol acetate [6]
MR002665 4-hydroxyestradiol 4-methoxyestradiol Unclear Estradiol cypionate [6]
MR002688 4-hydroxyestradiol 4-methoxyestradiol Unclear Estradiol valerate [6]
References
1 Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24.
2 Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology. 2003 Aug;144(8):3382-98.
3 The metabolism of estradiol; oral compared to intravenous administration J Steroid Biochem. 1985 Dec;23(6A):1065-70. doi: 10.1016/0022-4731(85)90068-8.
4 Evaluation of electrospray ionization and atmospheric pressure chemical ionization for simultaneous detection of estrone and its metabolites using high-performance liquid chromatography/tandem mass spectrometry J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Dec 1;860(1):49-56. doi: 10.1016/j.jchromb.2007.10.014.
5 Pharmacokinetics and pharmacodynamics of conjugated equine estrogens: chemistry and metabolism
6 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.

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