Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002716)
Formula
SVG example
O-Methylation
Reactant 4-hydroxyethinylestradiol Product 4-methoxyethinylestradiol
Reactant Info Product Info
Metabolic Enzyme Catechol O-methyltransferase (COMT) DME Info
Metabolic Type Conjugation - O-Methylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002722 Ethinyl estradiol 4-hydroxyethinylestradiol Oxidation - 4-Hydroxylation Ethinyl estradiol [1]
MR001646 17alpha-Ethinylestradiol 4-hydroxyethinylestradiol Oxidation - 4-Hydroxylation Mestranol [2], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007145 Unclear 4-methoxyethinylestradiol Conjugation - O-methylation Ethinylestradiol propanesulfonate [2], [3]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007146 4-methoxyethinylestradiol 4-methoxyethinylestradiol-glucuronide Conjugation - O-glucuronidation Ethinylestradiol propanesulfonate [2], [3]
MR007147 4-methoxyethinylestradiol 4-methoxyethinylestradiol-sulfate Conjugation - Sulfation Ethinylestradiol propanesulfonate [2], [3]
References
1 Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol Drug Metab Dispos. 2004 Nov;32(11):1299-303. doi: 10.1124/dmd.32.11..
2 Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
3 Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.

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