Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007146)
Formula Reactant 4-methoxyethinylestradiol Product 4-methoxyethinylestradiol-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - O-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002716 4-hydroxyethinylestradiol 4-methoxyethinylestradiol Conjugation - O-Methylation Ethinyl estradiol [1]
MR007145 Unclear 4-methoxyethinylestradiol Conjugation - O-methylation Ethinylestradiol propanesulfonate [1], [2]
MR001641 4-hydroxyethinylestradiol 4-methoxyethinylestradiol Conjugation - O-Methylation Mestranol [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007147 4-methoxyethinylestradiol 4-methoxyethinylestradiol-sulfate Conjugation - Sulfation Ethinylestradiol propanesulfonate [1], [2]
References
1 Genetic variation in the first-pass metabolism of ethinylestradiol, sex hormone binding globulin levels and venous thrombosis risk Eur J Intern Med. 2017 Jul;42:54-60. doi: 10.1016/j.ejim.2017.05.019.
2 Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.

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