Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002732)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Ethosuximide Product 2-ethyl-3-hydroxy-2-methylsuccinimide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2E1 (CYP2E1) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002731 Ethosuximide 2-(1-hydroxyethyl)-2-methylsuccinimide Oxidation - Hydroxylation Ethosuximide [1], [2], [3]
MR002730 Ethosuximide 2-(2-hydroxyethyl)-2-methylsuccinimide Oxidation - Hydroxylation Ethosuximide [1], [2], [4]
MR002733 Ethosuximide 2-ethyl-2-hydroxymethyl succinimide Oxidation - Hydroxylation Ethosuximide [1]
References
1 Chiral aspects of the human metabolism of ethosuximide Biopharm Drug Dispos. 2005 Sep;26(6):225-32. doi: 10.1002/bdd.454.
2 Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of ethosuximide by human hepatic microsomal enzymes. Xenobiotica. 2003 Mar;33(3):265-76.
3 Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction. Eur J Med Chem. 2021 Dec 15;226:113890. doi: 10.1016/j.ejmech.2021.113890.
4 The metabolism of ethosuximide Eur J Drug Metab Pharmacokinet. 1993 Oct-Dec;18(4):349-53. doi: 10.1007/BF03190184.

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