Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002817)
Formula
SVG example
Glucuronidation
Reactant Calcitriol Product Calcitriol 25-O-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002816 Calcitriol 1a,25R(OH)2-26,23S-lactone D3 Oxidation - Hydroxylation Calcitriol [1], [2]
MR002815 Calcitriol Calcitroic acid Oxidation - 24-Hydroxylation Calcitriol [1]
MR002814 Calcitriol 1a,25R(OH)2-26,23S-lactone D3 Oxidation - Hydroxylation Calcifediol [2]
MR002813 Calcitriol Calcitroic acid Oxidation - 24-Hydroxylation Calcifediol [2]
MR010849 Calcitriol 1,24,25(OH)2D3 Unclear - Unclear Cholecalciferol [3]
References
1 Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Mol Pharmacol. 2006 Jan;69(1):56-65.
2 Cytochromes P450 are essential players in the vitamin D signaling system. Biochim Biophys Acta. 2011 Jan;1814(1):186-99.
3 Vitamin D Metabolite Profile in Cholecalciferol- or Calcitriol-Supplemented Healthy and Mammary Gland Tumor-Bearing Mice

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