Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002855)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Ivacaftor Product M1 (hydroxymethyl-ivacaftor)
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002856 Ivacaftor M6 (ivacaftor-carboxylate) Oxidation - Oxidation Ivacaftor [1], [2]
References
1 PharmGKB summary: ivacaftor pathway, pharmacokinetics/pharmacodynamics Pharmacogenet Genomics. 2017 Jan;27(1):39-42. doi: 10.1097/FPC.0000000000000246.
2 Sensitivity of ivacaftor to drug-drug interactions with rifampin, a cytochrome P450 3A4 inducer. Pediatr Pulmonol. 2018 May;53(5):E6-E8.

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