Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002871)
Formula Reactant Pexidartinib Product N-glucuronide?metabolite
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A4 (UGT1A4) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010968 Pexidartinib Pexidartinib Metabolite M1 Multi-steps Reaction - Oxidative dealkylation glucuronidation Pexidartinib [1]
MR010970 Pexidartinib Pexidartinib Metabolite M2 Multi-steps Reaction - Epoxidation; epoxide htdrolysis Pexidartinib [1]
MR010971 Pexidartinib Pexidartinib Metabolite M3 Oxidation - Oxidation Pexidartinib [1]
MR010966 Pexidartinib Pexidartinib Metabolite M4 Oxidation - Oxidation Pexidartinib [1]
MR010969 Pexidartinib Pexidartinib Metabolite M5 Conjugation - Glucuronidation Pexidartinib [1]
References
1 Pharmacokinetics of the Multi-kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality

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