Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010970)
Formula Reactant Pexidartinib Product Pexidartinib Metabolite M2
Reactant Info Product Info
Metabolic Type Multi-steps Reaction - Epoxidation; epoxide htdrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002871 Pexidartinib N-glucuronide?metabolite Conjugation - Glucuronidation Pexidartinib [1]
MR010968 Pexidartinib Pexidartinib Metabolite M1 Multi-steps Reaction - Oxidative dealkylation glucuronidation Pexidartinib [2]
MR010971 Pexidartinib Pexidartinib Metabolite M3 Oxidation - Oxidation Pexidartinib [2]
MR010966 Pexidartinib Pexidartinib Metabolite M4 Oxidation - Oxidation Pexidartinib [2]
MR010969 Pexidartinib Pexidartinib Metabolite M5 Conjugation - Glucuronidation Pexidartinib [2]
References
1 FDA label of Pexidartinib. The 2020 official website of the U.S. Food and Drug Administration.
2 Pharmacokinetics of the Multi-kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality

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