Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002874)
Formula Reactant Phenylbutazone Product Beta-hydroxyphenylbutazone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002876 Phenylbutazone 4-hydroxyphenylbutazone Oxidation - Oxidation Phenylbutazone [1]
MR002873 Phenylbutazone Gamma-hydroxyphenylbutazone Oxidation - Oxidation Phenylbutazone [2]
MR002877 Phenylbutazone Glucuronides of phenylbutazone Conjugation - Glucuronidation Phenylbutazone [3]
MR002872 Phenylbutazone Oxyphenbutazone Oxidation - Oxidation Phenylbutazone [2]
MR002875 Phenylbutazone P,gamma-dihydroxyphenylbutazone Oxidation - Oxidation Phenylbutazone [1]
References
1 McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 1999. Bethesda, MD:American Society of Health-System Pharmacists, Inc. 1999 (Plus Supplements)., p. 1760
2 The Analysis of Phenylbutazone and Its Active Metabolite, Oxyphenbutazone, in Equine Tissues (Muscle, Kidney, and Liver), Urine, and Serum by LC-MS/MS
3 Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone. Arch Biochem Biophys. 2006 Oct 1;454(1):72-9.

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