Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002876)
Formula
SVG example
Oxidation
Reactant Phenylbutazone Product 4-hydroxyphenylbutazone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002874 Phenylbutazone Beta-hydroxyphenylbutazone Oxidation - Oxidation Phenylbutazone [1]
MR002873 Phenylbutazone Gamma-hydroxyphenylbutazone Oxidation - Oxidation Phenylbutazone [2]
MR002877 Phenylbutazone Glucuronides of phenylbutazone Conjugation - Glucuronidation Phenylbutazone [3]
MR002872 Phenylbutazone Oxyphenbutazone Oxidation - Oxidation Phenylbutazone [2]
MR002875 Phenylbutazone P,gamma-dihydroxyphenylbutazone Oxidation - Oxidation Phenylbutazone [1]
References
1 McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 1999. Bethesda, MD:American Society of Health-System Pharmacists, Inc. 1999 (Plus Supplements)., p. 1760
2 The Analysis of Phenylbutazone and Its Active Metabolite, Oxyphenbutazone, in Equine Tissues (Muscle, Kidney, and Liver), Urine, and Serum by LC-MS/MS
3 Identification of human UDP-glucuronosyltransferase isoform(s) responsible for the C-glucuronidation of phenylbutazone. Arch Biochem Biophys. 2006 Oct 1;454(1):72-9.

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