Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002900)
Formula Reactant Tacrine hydrochloride Product Glutathione conjugation of tacrine
Reactant Info Product Info
Metabolic Enzyme Glutathione S-transferase theta-1 (GSTT1) DME Info
Glutathione S-transferase mu-1 (GSTM1) DME Info
Metabolic Type Conjugation - Glutathione Conjugation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002896 Tacrine hydrochloride 1-hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002898 Tacrine hydrochloride 2-hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002902 Tacrine hydrochloride 3-hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002897 Tacrine hydrochloride 4- Hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002907 Tacrine hydrochloride 5,6-diOH-tacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002899 Tacrine hydrochloride 7-hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002905 Tacrine hydrochloride 8-hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.

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