Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002905)
Formula
SVG example
Hydroxylation
Reactant Tacrine hydrochloride Product 8-hydroxytacrine
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002896 Tacrine hydrochloride 1-hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002898 Tacrine hydrochloride 2-hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002902 Tacrine hydrochloride 3-hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002897 Tacrine hydrochloride 4- Hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002907 Tacrine hydrochloride 5,6-diOH-tacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002899 Tacrine hydrochloride 7-hydroxytacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
MR002900 Tacrine hydrochloride Glutathione conjugation of tacrine Conjugation - Glutathione Conjugation Tacrine hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002906 8-hydroxytacrine 7,8-diOH-tacrine Oxidation - Hydroxylation Tacrine hydrochloride [1]
References
1 Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218.
2 Combined glutathione-S-transferase M1 and T1 genetic polymorphism and tacrine hepatotoxicity. Clin Pharmacol Ther. 2000 Apr;67(4):432-7.

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