Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002993)
Formula
SVG example
Glucuronidation
Reactant Salicylic acid Product Phenolic glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A6 (UGT1A6) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002992 Aspirin Salicylic acid Unclear - Unclear Aspirin [1]
MR010983 Benzoic acid Salicylic acid Unclear - Unclear Benzoic acid [2]
MR011347 NCX-4016 SA Unclear - Unclear NCX-4016 [3]
MR006359 Salicin Salicylic acid Unclear Salicin [4]
MR010973 Salsalate Salicylic acid Unclear - Unclear Salsalate [5]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010984 Salicylic acid Beta-O-D-Glucosylsalcylic acid Unclear - Unclear Benzoic acid [2]
MR002995 Salicylic acid Gentistic acid Unclear - Unclear Aspirin [1]
MR006360 Salicylic acid Gentistic acid Unclear Salicin [4]
MR010985 Salicylic acid Methyl salicylate Unclear - Unclear Benzoic acid [2]
MR002994 Salicylic acid Salicylic acid acyl glucuronide Conjugation - Glucuronidation Aspirin [1]
MR010986 Salicylic acid Salicylic acid glucose ester Unclear - Unclear Benzoic acid [2]
MR002996 Salicylic acid Salicyluric acid Unclear - Unclear Aspirin [1]
MR006361 Salicylic acid Salicyluric acid Unclear Salicin [4]
References
1 Effect of common single-nucleotide polymorphisms in acetylsalicylic acid metabolic pathway genes on platelet reactivity in patients with diabetes Med Sci Monit. 2013 May 27;19:394-408. doi: 10.12659/MSM.883922.
2 Biosynthesis and metabolism of salicylic acid
3 Nitric oxide release and distribution following oral and intraperitoneal administration of nitroaspirin (NCX 4016) in the rat
4 Pharmacokinetics of salicin after oral administration of a standardised willow bark extract
5 AMPK: mediating the metabolic effects of salicylate-based drugs?

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