Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR002995)
Formula
SVG example
Unclear
Reactant Salicylic acid Product Gentistic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002992 Aspirin Salicylic acid Unclear - Unclear Aspirin [1]
MR010983 Benzoic acid Salicylic acid Unclear - Unclear Benzoic acid [2]
MR011347 NCX-4016 SA Unclear - Unclear NCX-4016 [3]
MR006359 Salicin Salicylic acid Unclear Salicin [4]
MR010973 Salsalate Salicylic acid Unclear - Unclear Salsalate [5]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010984 Salicylic acid Beta-O-D-Glucosylsalcylic acid Unclear - Unclear Benzoic acid [2]
MR010985 Salicylic acid Methyl salicylate Unclear - Unclear Benzoic acid [2]
MR002993 Salicylic acid Phenolic glucuronide Conjugation - Glucuronidation Aspirin [1]
MR002994 Salicylic acid Salicylic acid acyl glucuronide Conjugation - Glucuronidation Aspirin [1]
MR010986 Salicylic acid Salicylic acid glucose ester Unclear - Unclear Benzoic acid [2]
MR002996 Salicylic acid Salicyluric acid Unclear - Unclear Aspirin [1]
MR006361 Salicylic acid Salicyluric acid Unclear Salicin [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006504 ANW-43703 Gentistic acid Oxidation - Aromatic hydroxylation ANW-43703 [6]
MR004869 5-methoxysalicylic acid Gentistic acid Multi-steps Reaction - Demethylation; Reduction Naproxen [7]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006505 Gentistic acid Gentisuric acid Unclear ANW-43703 [6], [8]
MR004870 Gentistic acid Maleylpyruate Unclear Naproxen [7]
References
1 Effect of common single-nucleotide polymorphisms in acetylsalicylic acid metabolic pathway genes on platelet reactivity in patients with diabetes Med Sci Monit. 2013 May 27;19:394-408. doi: 10.12659/MSM.883922.
2 Biosynthesis and metabolism of salicylic acid
3 Nitric oxide release and distribution following oral and intraperitoneal administration of nitroaspirin (NCX 4016) in the rat
4 Pharmacokinetics of salicin after oral administration of a standardised willow bark extract
5 AMPK: mediating the metabolic effects of salicylate-based drugs?
6 Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. Eur J Pharm Sci. 2015 Jun 20;73:49-56.
7 Utilization of naproxen by Amycolatopsis sp. Poz 14 and detection of the enzymes involved in the degradation metabolic pathway
8 Polymorphisms of Aspirin-Metabolizing Enzymes CYP2C9, NAT2 and UGT1A6 in Aspirin-Intolerant Urticaria. Allergy Asthma Immunol Res. 2011 Oct;3(4):273-6.

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